Asociación Española
de Gastroenterología
Endoscopia Digestiva

Begoña González Suárez

El grupo de trabajo de endoscopia agrupa a los socios de AEG interesados en el diagnóstico, seguimiento y tratamiento de lesiones del tubo digestivo.

Effect of oral anticoagulants on the outcome of faecal immunochemical test.

Bujanda L1, Sarasqueta C2, Lanas Á3, Quintero E4, Cubiella J5, Hernandez V6, Morillas JD7, Perez-Fernández T8, Salas D9, Andreu M10, Carballo F11, Bessa X10, Portillo I12, Jover R13, Balaguer F14, Cosme A1, Castells A14; COLONPREV study investigators.

Br J Cancer. 2014 Mar 4;110(5):1334-7. PubMed PMID: 24496455.


We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening.


Individuals aged 50-69 years were invited to receive one FIT sample (cutoff 75 ng ml(-1)) between November 2008 and June 2011.


Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend=0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3-1.8; P=0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4-10.8; P=0.4). 


Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.