This prospective multicenter registry of the clinical practice of European gastroenterologists on the management of Helicobacter pylori infection and its treatment is supported by the European Helicobacter & Microbiota Study Group and the Asociación Española de Gastroenterología.
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(only countries with more than 100 patients included)
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Tepes B, Brglez Jurecic N, Denkovski M, Vujasinovic M, Kikec Z, Bednarik J, Tepes K, Cano-Català A, Parra P, Moreira L, Nyssen OP, Megraud F, O'Morain C, Gisbert JP; Hp-EuReg investigators. First-line therapy for Helicobacter pylori in Slovenia: Data from 2013-2023 of the European Registry on H. Pylori management. Helicobacter, 2025; 30:e70029. https://doi.org/10.1111/hel.70029
Tejedor-Tejada J, Martínez-Domínguez SJ, Hernández L, Cano-Català A, Parra P, Moreira L, Nyssen OP, Gisbert JP; Hp-EuReg investigators. Management of Helicobacter pylori infection in Spain beyond the data collected in the European Registry on H. pylori management (Hp-EuReg): results of a nationwide survey. Helicobacter, 2025; 30:e70028. Doi: 10.1111/hel.70028
Sinéad Marian Smith, Olga P Nyssen, Rebecca FitzGerald, Thomas J Butler, Deirdre McNamara, Asghar Qasim, Conor Costigan, Anna Cano-Catalá, Pablo Parra, Leticia Moreira, Francis Megraud, Colm O’Morain, Javier P Gisbert. First-line prescriptions and effectiveness of Helicobacter pylori eradication treatment in Ireland over a 10-year period: data from the European Registry on Helicobacter pylori management (Hp-EuReg). Antibiotics. In press
Michael Doulberis, Daniele Riva, Ioannis Linas, Patrick Mosler, Tom Völler, Imen Jallouli, Jürg Knuchel, Claudia Gregoriano, Pablo Gressot, Thrasyvoulos Gkretzios, Christos Kiosses, Thomas Balanis, Radu Tutuian, Hasan Kulaksiz, Anna Cano-Català, Pablo Parra, Leticia Moreira, Olga P. Nyssen, Francis Mégraud, Colm O’Morain, Thomas Kuntzen, Javier P. Gisbert. Effectiveness and Safety of First-Line Empirical Helicobacter pylori Eradication Regimens in Switzerland: An Interim Analysis from a Prospective Multicenter Registry (Hp-EuReg). Swiss Medical Weekly. In press
Nyssen, Olga P.; Montes, Nuria; Perez-Aisa, Maria; Martínez-Domínguez, Samuel J.; Tejedor-Tejada, Javier; Lucendo, Alfredo; Huguet, Jose Maria; Garre, Ana; Bujanda, Luis; Pabón-Carrasco, Manuel; Castro-Fernandez, Manuel; Perona, Monica; Ortiz Polo, Inmaculada; Nuñez, Oscar; Marcos, Maria Soledad; Gomez-Rodriguez, Blas; Loro, Antonio Moreno; Bermejo, Fernando; Barrio, Jesús; Iyo, Eduardo; Alonso, Eva Barreiro; Flores, Virginia; Keco Huerga, Alma; Mata-Romero, Pilar; Gomez-Camarero, Judith; Fernandez-Bermejo, Miguel; Dominguez-Cajal, Manuelk; Martín-Holgado, Daniel; Velayos, Benito; Planella, Montserrat; Alcaide, Noelia; Blanco, Ana Beatriz Pozo; Fernández, Luis; Pajares, Ramón; Alonso, Mónica Sánchez; Mejide, Pilar Pazo; Jiménez-Moreno, Manuel; Perelló, Antonia; Pascual-Mato, Marta; Albéniz, Eduardo; Hernández, Goretti; Gonzalez, Maria Fraile; Morán-Sánchez, Senador; Castro, Jesús Daniel Fernández de; Cano Catalá, Anna; Parra, Pablo; Moreira, Leticia; Megraud, Francis; O´Morain, Colm; Gisbert, Javier P. Effectiveness and safety of first-line non-bismuth quadruple concomitant therapy versus single-capsule bismuth quadruple therapy. Aliment Pharmacol Ther. In press
Viegas MI, Areia M, Elvas L, Marcos-Pinto R, Fernandes-Mendes H, Alves S, Brito D, Saraiva S, Cadime AT, Cano-Català A, Parra P, Moreira L, Megraud F, O'Morain C, Nyssen OP, Gisbert J. Effectiveness of First-line Empirical Treatment in Portugal: data from the European Registry on Helicobacter pylori Management (Hp-EuReg). GE Port J Gastroenterol. In press
Casas Deza D, Alcedo J, Lafuente M, López FJ, Perez-Aisa Á, Pavoni M, Tepes B, Jonaitis L, Castro-Fernandez M, Pabón-Carrasco M, Keco-Huerga A, Voynovan I, Bujanda L, Lucendo AJ, Jurecic NB, Denkovski M, Vologzanina L, Rodrigo L, Martínez-Domínguez SJ, Fadieienko G, Huguet JM, Abdulkhakov R, Abdulkhakov SR, Alcaide N, Velayos B, Hernández L, Bordin DS, Gasbarrini A, Kupcinskas J, Babayeva G, Gridnyev O, Leja M, Rokkas T, Marcos-Pinto R, Lerang F, Boltin D, Mestrovic A, Smith SM, Venerito M, Boyanova L, Milivojevic V, Doulberis M, Kunovsky L, Parra P, Cano-Català A, Moreira L, Nyssen OP, Megraud F, Morain CO, Gisbert JP; Hp-EuReg investigators. Probiotics prescribed with Helicobacter pylori eradication therapy in Europe: usage pattern, effectiveness, and safety: Results from the European Registry on Helicobacter pylori Management (Hp-EuReg). Am J Gastroenterol. In press
Babayeva GH, Mahmudov UR, Mammadov EE, Guliyev FV, Verdiyev EK, Machanov UR, Ibishev RF, Huseynov HM, Zalov ZS, Ismayilova SY, Hasanov RA, Ibrahimli HI, Cano-Català A, Parra P, Moreira L, Nyssen OP, Mégraud F, O'Morain C, Gisbert JP. Effectiveness of first-line empirical treatment in Azerbaijan: results from the European Registry on Helicobacter pylori Management (Hp-EuReg). Scientific-practical journal named after A.Aliyev “The Medicine and Science”. 2024;2(36):34-47. https://n9.cl/tw7cw0
Olmedo L, Calvet X, Gené E, Bordin DS, Voynovan I, Castro-Fernandez M, Pabón-Carrasco M, Keco-Huerga A, Perez-Aisa Á, Lucendo AJ, Rodrigo L, Sarsenbaeva AS, Khlinov IB, Fadieienko G, Zaytsev O, Lanas Á, Martínez-Domínguez SJ, Alfaro E, Jonaitis L, Núñez Ó, Pellicano R, Hernández L, Gridnyev O, Kupcinskas J, Gasbarrini A, Boltin D, Niv Y, Babayeva G, Marcos-Pinto R, Tepes B, Venerito M, Papp V, Lerang F, Leja M, Phull PS, Marlicz W, Doulberis M, Smith SM, Milivojevic V, Kunovsky L, Mestrovic A, Matysiak-Budnik T, Simsek H, Cano-Català A, Puig I, Moreira L, Parra P, Nyssen OP, Megraud F, O'Morain C, Gisbert JP; Hp-EuReg investigators. Evolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for Helicobacter pylori infection between 2013 and 2021: results from the European registry on H. pylori management (Hp-EuReg). Gut. 2024 Dec 10;74(1):15-25. DOI: 10.1136/gutjnl-2024-332804
Babayeva GH, Mahmudov UR, Mammadov EE, Guliyev FV, Verdiyev EKh, Machanov UR, Ibishev RF, Huseynov HM, Zalov ZS, Ismayilova SY, Hasanov RA, Ibrahimli HI, CanoCatalà A, Parra PP, Moreira L, Nyssen OP, Mégraud F, O'Morain C, Gisbert J. First-line therapy prescriptions in Azerbaijan: results from the European Registry on Helicobacter pylori management (Hp-EuReg). Scientific-practical journal named after A.Aliyev “The Medicine and Science”. 2024;1(35):55-65. https://n9.cl/oeo20
Křivinka J, Kunovský L, Vaculová J, Král J, Hrubá S, Šembera S, Tachecí I, Čavajdová P, Vašura A, Blaho M, Koňaříková P, Evinová E, Langner J, Vacková Z, Tesaříková P, Friedová N, Bauer P, Přidal D, Sychra P, Cano-Català A, Moreira L, Parra P, Mégraud F, O'Morain C, Nyssen O, Gisbert JP. First-line Helicobacter pylori empirical treatment in the Czech Republic (2019–2024) – initial insights from the European registry on H. pylori management (Hp-EuReg). Gastroent Hepatol. 2024;78(4):319–327. DOI: 10.48095/ccgh2024319
Huguet JM, Ferrer-Barceló L, Suárez P, Barcelo-Cerda S, Sempere J, Saracino IM, Fiorini G, Vaira D, Pérez-Aísa Á, Jonaitis L, Tepes B, Castro-Fernandez M, Pabón-Carrasco M, Keco-Huerga A, Voynovan I, Lucendo AJ, Lanas Á, Martínez-Domínguez SJ, Alfaro Almajano E, Rodrigo L, Vologzanina L, Bordin DS, Gasbarrini A, Babayeva G, Lerang F, Leja M, Kupčinskas J, Rokkas T, Marcos-Pinto R, Meštrović A, Gridnyev O, Phull PS, Smith SM, Boltin D, Buzás GM, Kral J, Şimşek H, Matysiak-Budnik T, Milivojevic V, Marlicz W, Venerito M, Boyanova L, Doulberis M, Capelle LG, Cano-Català A, Moreira L, Nyssen OP, Mégraud F, O'Morain C, Gisbert JP; Hp‐EuReg Investigators. Role of compliance in Helicobacter pylori eradication treatment: Results of the European Registry on H. pylori management. United European Gastroenterol J. 2024 Jul;12(6):691-704. DOI: 10.1002/ueg2.12569
Martínez-Domínguez SJ, Nyssen OP, Lanas Á, Alfaro E, Jonaitis L, Mahmudov U, Voynovan I, Gülüstan B, Rodrigo L, Fiorini G, Perez-Aisa Á, Tejedor-Tejada J, Tepes B, Vologzanina L, Mammadov E, Lerang F, Oğlu QFV, Bakulina NV, Abdulkhakov R, Tatiana I, Butler TJ, Sarsenbaeva AS, Bumane R, Lucendo AJ, Romano M, Bujanda L, Abdulkhakov SR, Zaytsev O, Pabón-Carrasco M, Keco-Huerga A, Denkovski M, Huguet JM, Perona M, Núñez Ó, Pavoni M, Fadieienko G, Alekseenko S, Smith SM, Hernández L, Kupcinskas J, Bordin DS, Leja M, Gasbarrini A, Gridnyev O, Cano-Català A, Parra P, Moreira L, Mégraud F, O'Morain C, Gisbert JP; Hp‐EuReg Investigators. Indications of Helicobacter pylori Eradication Treatment and Its Influence on Prescriptions and Effectiveness (Hp-EuReg). Helicobacter. 2024 Jul-Aug;29(4):e13111. DOI: 10.1111/hel.13111
Luzko I, Nyssen OP, Moreira L, Gisbert JP. Safety profile of Helicobacter pylori eradication treatments: literature review and updated data of the European Registry on Helicobacter pylori management (Hp-EuReg). Expert Opin Drug Saf. 2024 May;23(5):553-564. DOI: 10.1080/14740338.2024.2338245
Bujanda L, Nyssen OP, Ramos J, Bordin DS, Tepes B, Perez-Aisa A, Pavoni M, Castro-Fernandez M, Lerang F, Leja M, Rodrigo L, Rokkas T, Kupcinskas J, Jonaitis L, Shvets O, Gasbarrini A, Simsek H, Phull PS, Buzás GM, Machado JC, Boltin D, Boyanova L, Tonkić A, Marlicz W, Venerito M, Vologzanina L, Fadieienko GD, Fiorini G, Resina E, Muñoz R, Cano-Català A, Puig I, García-Morales N, Hernández L, Moreira L, Megraud F, Morain CO, Montes M, Gisbert JP; Hp-EuReg investigators; Hp-EuReg investigators. Effectiveness of Helicobacter pylori treatments according to antibiotic resistance. Am J Gastroenterol. 2024 Apr 1;119(4):646-654. DOI: 10.14309/ajg.0000000000002600
Pabón-Carrasco M, Keco-Huerga A, Castro-Fernández M, Saracino IM, Fiorini G, Vaira D, Pérez-Aísa Á, Tepes B, Jonaitis L, Voynovan I, Lucendo AJ, Lanas Á, Martínez-Domínguez SJ, Almajano EA, Rodrigo L, Vologzanina L, Brglez Jurecic N, Denkovski M, Bujanda L, Abdulkhakov RA, Huguet JM, Fernández-Salazar L, Alcaide N, Velayos B, Silkanovna Sarsenbaeva A, Zaytsev O, Ilchishina T, Barrio J, Bakulin I, Perona M, Alekseenko S, Romano M, Gravina AG, Núñez Ó, Gómez Rodríguez BJ, Ledro-Cano D, Pellicano R, Bogomolov P, Domínguez-Cajal M, Almela P, Gomez-Camarero J, Bordin DS, Gasbarrini A, Kupčinskas J, Cano-Català A, Moreira L, Nyssen OP, Mégraud F, O'Morain C, Gisbert JP; Hp-EuReg Investigators. Role of proton pump inhibitors dosage and duration in Helicobacter pylori eradication treatment: results from the European registry on H. pylori management (Hp-EuReg). United European Gastroenterol J. 2024 Feb;12(1):122-138. DOI: 10.1002/ueg2.12476
Pérez-Aisa A, Nyssen OP, Keco-Huerga A, Rodrigo L, Lucendo AJ, Gomez-Rodriguez BJ, Ortuño J, Perona M, Huguet JM, Núñez O, Fernandez-Salazar L, Barrio J, Lanas A, Iyo E, Mata Romero P, Fernández-Bermejo M, Gomez B, Garre A, Gomez-Camarero J, Lamuela LJ, Campillo A, de la Peña-Negro L, Dominguez Cajal M, Bujanda L, Burgos-Santamaría D, Bermejo F, González-Carrera V, Pajares R, Almela Notari P, Tejedor-Tejada J, Planella M, Jiménez I, Arguedas Lázaro Y, Cuadrado-Lavín A, Pérez-Martínez I, Amorena E, Gonzalez-Santiago JM, Angueira T, Flores V, Martínez-Domínguez SJ, Pabón-Carrasco M, Velayos B, Algaba A, Ramírez C, Alfaro Almajano E, Castro-Fernandez M, Alcaide N, Sanz Segura P, Cano-Català A, García-Morales N, Moreira L, Mégraud F, O’Morain C, Calvet X, Gisbert JP. Bismuth quadruple three-in-one single capsule three times a day increases effectiveness compared with the usual four times a day schedule: results from the European Registry on Helicobacter pylori Management (Hp-EuReg). Gut. 2023;72(11):2031-2037. DOI: 10.1136/gutjnl-2022-329259
Jonaitis P, Nyssen OP, Saracino IM, Fiorini G, Vaira D, Pérez-Aísa Á, Tepes B, Castro-Fernandez M, Pabón-Carrasco M, Keco-Huerga A, Voynovan I, Lucendo AJ, Lanas Á, Martínez-Domínguez SJ, Almajano EA, Rodrigo L, Vologzanina L, Brglez Jurecic N, Denkovski M, Bujanda L, Mahmudov U, Leja M, Lerang F, Babayeva G, Bordin DS, Gasbarrini A, Kupcinskas J, Gridnyev O, Rokkas T, Marcos-Pinto R, Phull PS, Smith SM, Tonkić A, Boltin D, Buzás GM, Šembera Š, Şimşek H, Matysiak-Budnik T, Milivojevic V, Marlicz W, Venerito M, Boyanova L, Doulberis M, Capelle LG, Cano-Català A, Moreira L, Mégraud F, O'Morain C, Gisbert JP, Jonaitis L. Comparison of the management of Helicobacter pylori infection between the older and younger European populations. Sci Rep. 2023;13(1):17235. DOI: 10.1038/s41598-023-43287-4
Nyssen OP, Pratesi P, Spínola MA, Jonaitis L, Pérez-Aísa Á, Vaira D, Saracino IM, Pavoni M, Fiorini G, Tepes B, Bordin D, Voynovan I, Lanas A, Martínez-Domínguez SJ, Alfaro E, Bujanda L, Castro-Fernández M, Hernández L, Gasbarrini A, Kupčinskas J, Lerang F, Smith S, Gridnyev O, Leja M, Rokkas T, Pinto RM, Tonkic A, Marlicz W, Milivojevic V, Simsek H, Kunovsky L, Papp V, Phull P, Venerito M, Boyanova L, Boltin D, Niv Y, Matysiak-Budnik T, Doulberis M, Dobru D, Lamy V, Capelle LG, Nikolovska Trpcevska E, Moreira L, Cano-Català A, Parra P, Megraud F, O'Morain C, Ortega GJ, Gisbert JP, On behalf of the Hp-EuReg Investigators. Analysis of clinical phenotypes through machine learning of first-line H.pylori treatment in Europe during the period 2013-2022: Data from the European Registry on H.pylori Management (Hp-EuReg). Antibiotics (Basel).2023;12,1427. DOI: https://www.mdpi.com/2079-6382/12/9/1427
N García-Morales, A Pérez-Aisa, G Fiorini, B Tepes, M Castro-Fernández, AJ Lucendo, I Voynovan, L Bujanda, A Garre, L Rodrigo, SJ Martínez-Domínguez, M Denkovski, JM Huguet, L Jonaitis, R Bumane, O Zaytsev, P Mata Romero, J Barrio, L Fernández-Salazar, AS Sarsenbaeva, I Ortiz, S Alekseenko, IM Saracino, D Vaira, A Keco-Huerga, D Bordin, A Gasbarrini, F Lerang, T Rokkas, J Kupcinskas, M Leja, G Babayeva, R Marcos Pinto, A Tonkic, S Smith, P Phull, GM Buzas, H Simsek, D Boltin, O Gridnyev, M Venerito, V Milivojevic, N Torà, A Cano-Català, L Moreira, OP Nyssen, F Mégraud, C O’Morain, JP Gisbert, I Puig, On behalf of the Hp-EuReg Investigators. Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management. J Clin Med. 2023;12(13),4363. DOI: 10.3390/jcm12134363
D Burgos-Santamaría, OP Nyssen, D Vaira, Y Niv, B Tepes, G Fiorini, A Pérez-Aisa, L Rodrigo-Sáez, M Castro-Fernández, R Pellicano, I Modolell, P Mata Romero, JC Delchier, JA Ortuño, M Areia, J Barrio, P Phull, L Bujanda, N Brglez Jurecic, J Pérez-Lasala, AJ Lucendo, J Gomez-Camarero, L Jonaitis, X Calvet, J Santos-Fernández, I Puig, F Mégraud, C O’Morain, JP Gisbert, On behalf of the Hp-EuReg Investigators. Empirical rescue treatment in third and subsequent lines of Helicobacter pylori infection: 8-year experience from the European Registry on H. pylori Management (Hp-EuReg) on in 2,144 patients. Gut. 2023;72:1054–1072. DOI: 10.1136/gutjnl-2022-328232
Бордин Д.С., Войнован И.Н., Сарсенбаева А.С., Зайцев О.В., Абдулхаков Р.А., Бакулина Н.В., Бакулин И.Г., Осипенко М.Ф., Ливзан М.А., Алексеенко С.А., Тарасова Л.В., Тарасова Г.Н., Богомолов П.О., Маев И.В., Андреев Д.Н., Абдулхаков С.Р., Старостин Б.Д., Баканова Н.В., Кононова А.Г., Колбасников С.В., L Moreira, F Mégraud, C O'Morain, OP Nyssen, JP Gisbert от имени научного комитета и исследователей Hp-EuReg. Effectiveness of empirical H. pylori eradication therapy with furazolidone in Russia: results from the European Registry on Helicobacter pylori Management (Hp-EuReg) Terapevticheskii arkhiv. 2023;95(2):120–129. DOI: https://doi.org/10.26442/00403660.2023.02.202107
Gatta L, Nyssen OP, Fiorini G, Saracino IM, Pavoni M, Romano M, Gravina AG, Granata L, Pellicano R, Gasbarrini A, Di Leo A, Losurdo G, Franceschi F, Nardone G, Rocco A, Dore MP, Farinati F, Ghisa M, Bellini M, Holton J, Puig I, Vaira D, Borghi C, Mégraud F, O'Morain C, Gisbert JP. Effectiveness of first and second-line empirical treatment in Italy: Results of the European registry on Helicobacter pylori management. United European Gastroenterol J. 2023 Feb;11(1):103-113. DOI: 10.1002/ueg2.12348.
Milivojevic V,Babic I, Kekic D, Rankovica I, Sagdatie S, Panic N, Sekulic Spasicg I, Krstica M, Milosavljevic T, Moreira L, Nyssen OP, Mégraud F, O' Morain C, Gisbert JP. Current trends in the management of Helicobacter pylori infection in Serbia: preliminary results from the European registry on H. pylori management (Hp-EuReg).Digestive Diseases. 2023;41(3):377-386. DOI: 10.1159/000528389
Fadieienko GD, Shvets OV, Moreira L, Nyssen OP, Mégraud F, O’Morain C, Gisbert JP, Gridnyev OE. Current trends in the treatment of H. pylori infection in Ukraine: results of the European Registry on Helicobacter pylori Management (Hp-EuReg). J Modern Gastroenterology. 2022 Sep;29:5-13. DOI: 10.30978/MG-2022-3-5
Nyssen OP, Vaira D, Pérez Aísa A, Rodrigo L, Castro-Fernandez M, Jonaitis L, Tepes B, Vologzhanina L, Caldas M, Lanas A, Lucendo AJ, Bujanda L, Ortuño J, Barrio, Huguet JM, Voynovan I, Perez Lasala J, Silkanovna Sarsenbaeva A, Fernandez-Salazar L, Molina-Infante J, Brglez Jurecic N, Areia M, Gasbarrini A, Kupčinskas J, Bordin D, Marcos-Pinto R, Lerang F, Leja M, Buzas GM, Niv Y, Rokkas T, Phull P, Smith S, Shvets O, Venerito M, Milivojevic V, Simsek I, Lamy V, Bytzer P, Boyanova L, Kunovský L, Beglinger C, Doulberis M, Marlicz W, Goldis A, Tonkić A, Capelle L, Puig I, Megraud F, O’ Morain C, Gisbert JP, on behalf of the Hp-EuReg Investigators. Empirical second-line therapy in 5,000 patients of the European Registry on Helicobacter pylori Management (Hp-EuReg). Clin Gastroenterol Hepatol. 2022 Oct;20(10):2243-2257. DOI: 10.1016/j.cgh.2021.12.025
Nyssen OP, Moreira L, García-Morales N, Cano-Català A, Puig I, Megraud F, O'Morain C, Gisbert JP. European Registry on Helicobacter pylori Management (Hp-EuReg): Most relevant results for clinical practice. Front. Gastroenterol. 2022 Aug 17;1:965982. DOI: 10.3389/fgstr.2022.965982
Fernández-Salazar L, Campillo A, Rodrigo L, Pérez-Aisa Á, González-Santiago JM, Segarra Ortega X, Denkovski M, Brglez Jurecic N, Bujanda L, Gómez Rodríguez BJ, Ortuño J, Georgopoulos S, Jonaitis L, Puig I, Nyssen OP, Mégraud F, O'Morain C, Gisbert JP. Effectiveness and Safety of High-Dose Dual Therapy: Results of the European Registry on the Management of Helicobacter pylori Infection (Hp-EuReg). J Clin Med. 2022 Jun 20;11(12):3544. DOI: 10.3390/jcm11123544
Nyssen OP, Vaira D, Saracino IM, Fiorini G, Caldas M, Bujanda L, Pellicano R, Keco-Huerga A, Pabón-Carrasco M, Oblitas Susanibar E, Di Leo A, Losurdo G, Pérez Aísa A, Gasbarrini A, Boltin D, Smith S, Phull P, Rokkas T, Lamaraque D, Cano-Català A, Puig I, Mégraud F, O'Morain C, Gisbert JP. Experience with Rifabutin-Containing Therapy in 500 Patients from the European Registry on Helicobacter pylori Managament (Hp-EuReg). J Clin Med. 2022 Mar 16;11(6):1658. DOI: 10.3390/jcm11061658.
Rokkas T, Georgopoulos S, Michopoulos S, Ntouli V, Liatsos C, Puig I, Nyssen OP, Mégraud F, O'Morain C, Gisbert JP, On behalf of the Hp-EuReg Investigators. Assessment of First-Line Eradication Treatment in Greece: Data from the European Registry on Helicobacter pylori Management (Hp-EuReg). Ann Gastroenterol. Jan-Feb 2022;35(1):42-47. DOI: 10.20524/aog.2021.0670.
Nyssen OP, Vaira D, Tepes B, Kupcinskas L, Bordin D, Pérez-Aisa A, Gasbarrini A, Castro-Fernández M, Bujanda L, Garre A, Lucendo A, Vologzhanina L, Brglez Jurecic N, Rodrigo-Sáez L, Huguet Malavés JM, Voynovan I, Perez Lasala J, Mata Romero P, Vujasinovic M, Abdulkhakov R, Barrio J, Fernandez-Salazar L, Mégraud F, O’Morain C, Gisbert JP. Room for improvement in the treatment of Helicobacter pylori infection: lessons from the European Registry on H. pylori management (Hp-EuReg) J Clin Gastroenterol. 2022 Feb 1;56(2):e98-e108. DOI: 10.1097/MCG.0000000000001482.
Bujanda L, Nyssen OP, Vaira D, Saracino IM, Fiorini G, Lerang F, Georgopoulos S, Tepes B, Heluwaert F, Gasbarrini A, Rokkas T, Bordin D, Smith S, Lamy V, Caldas M, Resina E, Muñoz R, Cosme Á, Puig I, Megraud F, O'Morain C, Gisbert JP. Antibiotic resistance prevalence and trends in patients infected with Helicobacter pylori in the period 2013-2020: results of the European Registry on H. pylori Management (Hp-EuReg). Antibiotics (Basel). 2021 Sep 1;10(9):1058. DOI: 10.3390/antibiotics10091058.
Caldas M, Pérez-Aisa Á, Tepes B, Keco-Huerga A, Bujanda L, Lucendo AJ, Rodrigo L, Vaira D, Fernández-Salazar L, Huguet JM, Pérez-Lasala J, Jurecic NB, Fadeenko G, Barrio J, Areia M, Ortuño J, Pellicano R, Leja M, Molina-Infante J, Bogomolov P, Alekseenko S, Domínguez-Cajal M, Gómez-Camarero J, Ntouli V, Martínez-Domínguez SJ, Ruiz-Zorrilla R, Núñez O, Sarsenbaeva AS, Almela P, Phull P, Espada M, Puig I, Nyssen OP, Mégraud F, O'Morain C, Gisbert JP, On Behalf Of The Hp-EuReg Investigators. The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg). Antibiotics (Basel). 2021 Aug 11;10(8):965. DOI: 10.3390/antibiotics10080965.
Tepes B, Brglez Jurecic N, Tepes K, Espada Sanchez M, Nyssen OP, O'Morain C, Mégraud F, Gisbert JP. Helicobacter pylori Eradication Rates in Slovenia in the Period from 2017 to 2019: Data from the European Registry on H. pylori Management. Dig Dis. 2021;39(4):318-324. DOI:10.1159/000512506.
Jonaitis P, Kupcinskas J, Nyssen OP, Puig I, Gisbert JP, Jonaitis L. Evaluation of the Effectiveness of Helicobacter pylori Eradication Regimens in Lithuania during the Years 2013–2020: Data from the European Registry on Helicobacter pylori Management (Hp-EuReg). Medicina 2021; 57(7),642. www.mdpi.com/1648-9144/57/7/642
Nyssen OP, Perez-Aisa A, Tepes B, Castro-Fernandez M, Kupcinskas J, Jonaitis L, Bujanda L, Lucendo A, Brglez Jurecic N, Perez-Lasala J, Shvets O, Fadeenko G, Huguet JM, Kikec Z, Bordin D, Voynovan I, Leja M, Machado JC, Areia M, Fernandez-Salazar L, Rodrigo L, Alekseenko S, Barrio J, Ortuño J, Perona M, Vologzhanina L, Mata Romero P, Zaytsev O, Rokkas T, Georgopoulos S, Pellicano R, Buzas GM, Modolell I, Gomez Rodriguez BJ, Simsek I, Simsek C, Roldan Lafuente M, Ilchishina T, Gomez Camarero J, Dominguez-Cajal M, Ntouli V, Nikolaevna Dekhnich N, Phull P, Nuñez O, Lerang F, Venerito M, Heluwaert F, Tonkic A, Caldas M, Puig I, Megraud F, O'Morain C, Gisbert JP. Adverse Event Profile During the Treatment of Helicobacter pylori: A Real-World Experience of 22,000 Patients From the European Registry on H. pylori Management (Hp-EuReg). Am J Gastroenterol.2021 Jun 1;116(6):1220-1229. DOI: 10.14309/ajg.0000000000001246.
Nyssen OP, Perez Aisa A, Castro Fernandez M, Pellicano R, Huguet JM, Rodrigo L, Ortuño J, Gomez Rodriguez BJ, M Pinto RM, Areia M, Perona M, Nuñez O, Romano M, Gravina AG, Pozzati L, Fernandez Bermejo M, Venerito M, Malfertheiner P, Fernanadez Salazar L, Gasbarrini A, Vaira D, Puig I, Megraud F, O'Morain C, Gisbert JP, Hp-EuReg investigators. European Registry on Helicobacter pylori Management (Hp-EuReg): Single capsule bismuth quadruple therapy is effective in real-world clinical practice. United European Gastroenterol J 2021; 9(1):38-46. DOI: 10.1177/2050640620972615.
Boltin D, Beniashvili Z, Lahat A, Hirsch J, Nyssen OP, Mégraud F, O'Morain C, Gisbert JP, Niv Y. European Registry on Helicobacter pylori management (Hp-EuReg): First-line Therapy in Israel. Isr Med Assoc J 2021; 23(1):38-42. PMID: 33443341.
Nyssen OP, Bordin D, Tepes B, Pérez-Aisa Á, Vaira D, Caldas M, Bujanda L, Castro-Fernandez M, Lerang F, Leja M, Rodrigo L, Rokkas T, Kupcinskas L, Pérez-Lasala J, Jonaitis L, Shvets O, Gasbarrini A, Simsek H, Axon ATR, Buzás G, Machado JC, Niv Y, Boyanova L, Goldis A, Lamy V, Tonkic A, Przytulski K, Beglinger C, Venerito M, Bytzer P, Capelle L, Milosavljević T, Milivojevic V, Veijola L, Molina-Infante J, Vologzhanina L, Fadeenko G, Ariño I, Fiorini G, Garre A, Garrido J, F Pérez C, Puig I, Heluwaert F, Megraud F, O'Morain C, Gisbert JP. European Registry on Helicobacter pylori management (Hp-EuReg): patterns and trends in first-line empirical eradication prescription and outcomes of 5 years and 21 533 patients. Gut 2021 Jan;70(1):40-54. DOI:10.1136/gutjnl-2020-321372. Epub 2020 Sep 21.
Abdulkhakov SR, Bordin DS, Abdulkhakov RA, Safina DD, Gizdatullina AR, Gimadieva LZ, Safina GM, Ziyatdinov AI, Maturina AM, Nyssen OP, Megraud F, O'Morain C, Gisbert JP. European Registry on the management of Helicobacter pylori infection: features of diagnosis and treatment in Kazan. Ter Arkh 2020; 92(8):52-59. DOI: 10.26442/00403660.2020.08.000758
Caldas M, Pérez-Aisa Á, Castro-Fernández M, Bujanda L, Lucendo AJ, Rodrigo L, Huguet JM, Pérez-Lasala J, Molina-Infante J, Barrio J, Fernández-Salazar L, Lanas Á, Perona M, Domínguez-Cajal M, Ortuño J, Gómez-Rodríguez BJ, Almela P, Botargués JM, Núñez Ó, Modolell I, Gómez J, Ruiz-Zorrilla R, De la Coba C, Huerta A, Iyo E, Pozzati L, Antón R, Barenys M, Angueira T, Fernández-Bermejo M, Campillo A, Alcedo J, Pajares-Villaroya R, Mego M, Bermejo F, Dominguez-Jiménez JL, Titó L, Fernández N, Pabón-Carrasco M, Cosme Á, Mata-Romero P, Alcaide N, Ariño I, Di Maira T, Garre A, Puig I, Nyssen OP, Megraud F, O’Morain C, Gisbert JP. European Registry on Helicobacter pylori Management: Effectiveness of First and Second-Line Treatment in Spain. Antibiotics 2020; 10: E13. DOI: 10.3390/antibiotics10010013.
Nyssen OP, Perez-Aisa A, Rodrigo L, Castro M, Mata Romero P, Ortuño J, Barrio J, Huguet JM, Modollel I, Alcaide N, Lucendo A, Calvet X, Perona M, Gomez B, Gomez Rodriguez BJ, Varela P, Jimenez-Moreno M, Dominguez-Cajal M, Pozzati L, Burgos D, Bujanda L, Hinojosa J, Molina-Infante J, Di Maira T, Ferrer L, Fernández-Salazar L, Figuerola A, Tito L, de la Coba C, Gomez-Camarero J, Fernandez N, Caldas M, Garre A, Resina E, Puig I, O'Morain C, Megraud F, Gisbert JP. Bismuth quadruple regimen with tetracycline or doxycycline versus three-in-one single capsule as third-line rescue therapy for Helicobacter pylori infection: Spanish data of the European Helicobacter pylori Registry (Hp-EuReg). Helicobacter. 2020 Oct;25(5):e12722. DOI: 10.1111/hel.12722.
Bordin DS, Voynovan IN, Embutnieks YV, Nyssen OP, Megraud F, O Morain C, Perez-Gisbert J. [European registry on Helicobacter pylori management (Hp-EuReg) as a tool to evaluate and improve clinical practice in Moscow]. Ter Arkh. 2020 Apr 27;92(2):12-18. Russian. DOI: 10.26442/00403660.2020.02.000567.
Nyssen OP, Pérez-Aisa Á, Tepes B, Rodrigo-Sáez L, Romero PM, Lucendo A, Castro-Fernández M, Phull P, Barrio J, Bujanda L, Ortuño J, Areia M, Brglez Jurecic N, Huguet JM, Alcaide N, Voynovan I, María Botargues Bote J, Modolell I, Pérez Lasala J, Ariño I, Jonaitis L, Dominguez-Cajal M, Buzas G, Lerang F, Perona M, Bordin D, Axon T, Gasbarrini A, Marcos Pinto R, Niv Y, Kupcinskas L, Tonkic A, Leja M, Rokkas T, Boyanova L, Shvets O, Venerito M, Bytzer P, Goldis A, Simsek I, Lamy V, Przytulski K, Kunovský L, Capelle L, Milosavljevic T, Caldas M, Garre A, Mégraud F, O'Morain C, Gisbert JP; Hp-EuReg Investigators. Helicobacter pylori first-line and rescue treatments in patients allergic to penicillin: Experience from the European Registry on H pylori management (Hp-EuReg). Helicobacter. 2020 Jun;25(3):e12686. DOI: 10.1111/hel.12686. .
Buzás GM, Nyssen OP, Mégraud F, O'Morain C, Gisbert JP. Páneurópai regiszter: a Helicobacter pylori-fertőzés kezelése. Ferencvárosi adatok, 2013–2019 [Pan-European Registry on Helicobacter pylori management. Results from Ferencváros, Budapest, 2013-2019]. Orv Hetil. 2019 Nov;160(47):1856-1863. Hungarian. DOI: 10.1556/650.2019.31553.
McNicholl AG, O'Morain CA, Megraud F, Gisbert JP; As Scientific Committee of the Hp-Eureg on Behalf of the National Coordinators. Protocol of the European Registry on the management of Helicobacter pylori infection (Hp-EuReg). Helicobacter. 2019 Oct;24(5):e12630. DOI: 10.1111/hel.12630.
McNicholl AG, Bordin DS, Lucendo A, Fadeenko G, Fernandez MC, Voynovan I, Zakharova NV, Sarsenbaeva AS, Bujanda L, Perez-Aisa Á, Vologzhanina L, Zaytsev O, Ilchishina T, Coba C, Lasala JP, Alekseenko S, Modolell I, Molina-Infante J, Ruiz-Zorrilla Lopez R, Alonso-Galan H, Moreno NF, Hinojosa J, Santaella I, Varela P, Gonzalez-Cordero PL, Barrio J, Dominguez-Jimenez JL, Nuñez O, Alcedo J, Nyssen OP, Caldas M, Donday MG, Shvetz O, Megraud F, O'Morain C, Gisbert JP. Combination of Bismuth and Standard Triple Therapy Eradicates Helicobacter pylori Infection in More than 90% of Patients. Clin Gastroenterol Hepatol. 2020 Jan;18(1):89-98. DOI:10.1016/j.cgh.2019.03.048.
Bordin DS, Embutnieks YV, Vologzhanina LG, Ilchishina TA, Voynovan IN, Sarsenbaeva AS, Zaitsev OV, Alekseenko SA, Abdulkhakov RA, Dehnich NN, Osipenko MF, Livzan MA, Tsukanov VV, Burkov SG, Bakulina NV, Plotnikova EY, Tarasova LV, Maev IV, Kucheryavyi YA, Baryshnikova NV, Butov MA, Kolbasnikov SV, Pakhomova AL, Zhestkova TV, Baranovsky AY, Abdulhakov SR, Ageeva EA, Lyalyukova EA, Vasyutin AV, Golubev NN, Savilova IV, Morkovkina LV, Kononova AG, Megraud F, O'Morain C, Ramas M, Nyssen OP, McNicholl AG, Gisbert JP. [European registry Helicobacter pylori (Hp-EuReg): how has clinical practice changed in Russia from 2013 to 2018 years]. Ter Arkh. 2019 Feb 15;91(2):16-24. Russian. DOI: 10.26442/00403660.2019.02.000156.
Bordin DS, Embutnieks YV, Vologzhanina LG, Il'chishina TA, Voinovan IN, Sarsenbaeva AS, Alekseenko SA, Zaitsev OV, Abdulkhakov RA, Osipenko MF, Livzan MA, Tsukanov VV, Burkov SG, Bakulina NV, Dekhnich NN, Tarasova LV, Plotnikova EY, Maev IV, Kucheryavyi YA, Baryshnikova NV, Butov MA, Kolbasnikov SV, Pakhomova AL, Zhestkova TV, Baranovskii AY, Abdulkhakov SR, Ageeva EA, Lyalyukova EA, Vasyutin AV, Golubev NN, Savilova IV, Morkovkina LV, Kononova AG, Megraud F, O'Morain C, Ramas M, Nyssen OP, McNicholl AG, Gisbert JP. European Registry on the management of Helicobacter pylori infection (Hp-EuReg): analysis of 2360 patients receiving first-line therapy in Russia. Ter Arkh. 2018 Feb 15;90(2):35-42. DOI: 10.26442/terarkh201890235-42.
Tepes B, Kastelic M, Vujasinovic M, Lampic P, Seruga M, Jurecic NB, Nyssen OP, Donday MG, O'Morain C, Megraud F, McNicholl AG, Gisbert JP. Helicobacter Pylori Treatment Results in Slovenia in the Period 2013-2015 as a Part of European Registry on Helicobacter Pylori Management. Radiol Oncol. 2017 Dec 7;52(1):1-6. DOI: 10.1515/raon-2017-0055.
Bordin DS, Yanova OB, Abdulkhakov RA, Tsukanov VV, Livzan MA, Burkov SG, Zakharova NV, Plotnikova EY, Osipenko MF, Tarasova LV, Maev IV, Kucheryavyi YA, Butov MA, Sablin OA, Kolbasnikov SV, Voinovan IN, Abdulkhakov SR, Vasyutin AV, Lyalyukova EA, Golubev NN, Savilova IV, Grigoryeva LV, Kononova AG, O'Morain C, Ramas M, Mcnicholl AG, Gisbert JP. [European Registry on the management of Helicobacter pylori infection (Hp-EuReg protocol): The first results of Russian centers]. Ter Arkh. 2016;88(2):33-38. Russian. DOI: 10.17116/terarkh201688233-38.
Gisbert JP, Romano M, Gravina AG, Solís-Muñoz P, Bermejo F, Molina-Infante J, Castro-Fernández M, Ortuño J, Lucendo AJ, Herranz M, Modolell I, Del Castillo F, Gómez J, Barrio J, Velayos B, Gómez B, Domínguez JL, Miranda A, Martorano M, Algaba A, Pabón M, Angueira T, Fernández-Salazar L, Federico A, Marín AC, McNicholl AG. Helicobacter pylori second-line rescue therapy with levofloxacin- and bismuth-containing quadruple therapy, after failure of standard triple or non-bismuth quadruple treatments. Aliment Pharmacol Ther. 2015 Apr;41(8):768-75. DOI: 10.1111/apt.13128.
Molina-Infante J, Lucendo AJ, Angueira T, Rodriguez-Tellez M, Perez-Aisa A, Balboa A, Barrio J, Martin-Noguerol E, Gomez-Rodriguez BJ, Botargues-Bote JM, Gomez-Camarero J, Huerta A, Modolell I, Ariño I, Herranz-Bachiller MT, Bermejo F, McNicholl AG, O'Morain C, Gisbert JP; European Registry on H. pylori management (Hp‐EuReg). Optimised empiric triple and concomitant therapy for Helicobacter pylori eradication in clinical practice: the OPTRICON study. Aliment Pharmacol Ther. 2015 Mar;41(6):581-9. DOI: 10.1111/apt.13069.
Relationship between antibiotics consumption and antibiotic bacterial resistances and its effect on H. pylori eradication treatments (submitted)
Prescriptions and effectiveness of alternative and infrequent Helicobacter pylori eradication regimens
Lack of usefulness of literature-based Helicobacter pylori resistance data for predicting first-line empirical treatment effectiveness
Classic bismuth quadruple therapy: influence of the dose and administration scheme on the therapy effectiveness and safety.
Sixth-line eradication therapy against Helicobacter pylori : preliminary data from the Hp-EuReg
Messages learned from the 10-year Hp-EuReg experience: recommendations for the clinical practice
Clinical performance of the gastroenterologist in the management of H. pylori infection: changes through 10-year experience of the European Registry on H. pylori management (Hp-EuReg)
Comprehensive literature review of H. pylori resistance rates in Europe (including data from the Hp-EuReg)
PCR-detected bacterial resistance rate across Europe and treatment effectiveness
Factors associated with the lack of follow-up in Helicobacter pylori eradication treatment
Effectiveness of repeated use of amoxicillin–clarithromycin triple therapy and bismuth quadruple therapy after prior failure
Patterns and H. pylori treatment effectiveness in Croatia
Prescriptions and effect of H. pylori antibiotic resistance on eradication treatments in Norway
H. pylori treatment prescriptions in Latvia: gastroenterologist versus general practitioners
Effectiveness of empirical first-line therapy in Russia from 2013 to 2021: analysis of 15 Russian cities
Effectiveness of rebamipide-containing first-line empirical eradication therapy in Russia
The Poland experience on first-line empirical therapy
Rescue therapy for H. pylori infection in Slovenia
Real-World Indications for First-Line H. pylori Eradication in Germany
The UK experience with the first-line empirical eradication treatment against H. pylori
The Standard Operating Procedure (SOP) of the Hp-EuReg is intended to ensure the correct pathway for participating, recruiting patients, consulting and evaluating data, preparing studies and disseminating the project results.
By agreeing to participate in the study, investigators commit to the Scientific Committee and the other investigators, taking an active part in patient inclusion, promoting participation with other gastroenterologists or centres that may become involved, and disseminating the project to encourage active patient recruitment.
The SOP is available at https://redcap.aegastro.es/redcap_v12.3.2/FileRepository/index.php?pid=345, only accessible with individual investigators' REDCap credentials.
PMID | DOI
Helicobacter pylori selectively infects the human stomach, being the most prevalent chronic infection in the world. H pylori presence causes chronic gastritis in 100% of infected patients and is the major cause of relevant diseases such as atrophic gastritis, peptic ulcer disease, and gastric cancer; it is for this reason that from a public health standpoint, it is considered a high-impact pathogen, responsible of a significant morbidity and mortality. Nowadays, there are consensus and clinical guidelines regarding the infection management at a European level and in most of European countries, but no data have shown the level of implementation of these recommendations. The high costs that this infection carries both socially and to the health system require the continuous and systematic assessment of the diagnostic and treatment strategies, as well as the accessibility to diagnostic methods and most efficient drugs.
To register the diagnosis, management strategies, and treatment of H pylori-infected adult patients in the Digestive Services outpatient clinics throughout Europe.
Noninterventionist prospective multicentre international Registry promoted by the European Helicobacter and Microbiota Study Group. National Coordinators will select recruiting gastroenterologists in their country that will register the H pylori-related routine clinical practice consultations they receive in an electronic case report form (e-CRF) provided by AEG-REDCap. Variables retrieved will include clinical, diagnostic, treatment, eradication confirmation, and outcome data. The database will allow researchers to perform specific subanalyses after approval by the Scientific Committee of the study.
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