El Grupo de Trabajo de Enfermedad Inflamatoria Intestinal de la AEG está formado mayoritariamente por miembros del Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa (GETECCU). Es objetivo primordial del grupo el estudio y la investigación de la Enfermedad Inflamatoria Intestinal (EII): enfermedad de Crohn y colitis ulcerosa y la homologación de criterios clínico-terapéuticos en el diagnóstico y tratamiento de la misma.
Autores: Barreiro-de Acosta M, García-Bosch O, Gordillo J, Mañosa M, Menchén L, Souto R, Marin-Jimenez I; Grupo Joven GETECCU.
Referencia: Eur J Gastroenterol Hepatol. 2012 Jul;24(7):756-8. doi: 10.1097/MEG.0b013e3283525a7b.
In refractory pouchitis, infliximab (IFX) has been used as rescue therapy; however, there is no clinical evidence for the use of adalimumab (ADA). The aim of this study was to report the efficacy of ADA in patients with refractory pouchitis previously treated with IFX.
A retrospective, open-label, case series was designed. Patients with chronic refractory pouchitis treated with ADA were included. All patients were previously treated with IFX. The short-term and mid-term efficacy of ADA was evaluated.
Eight patients with chronic refractory pouchitis treated with ADA were included. After 8 weeks, 13% of the patients achieved remission and 62% showed a clinical response. At week 26, 13% achieved remission and 38% showed a clinical response. At week 52, 50% of the patients avoided a permanent ileostomy but only 25 achieved remission.
ADA treatment was found to be an alternative for patients with chronic refractory pouchitis previously treated with IFX.