Asociación Española
de Gastroenterología
Esófago-Estómago-Duodeno

Pilar García Iglesias
Coordinador

El grupo de trabajo de Esófago-Estómago-Duodeno (EED) fue constituido en 1999 y desde entonces agrupa a los socios de AEG interesados en la fisiología y las enfermedades de los órganos mencionados, y recoge algunas otras patologías gastroenterológicas que pueden afectar a tramos más distales del tubo digestivo.


[Pan-European Registry on Helicobacter pylori management. Results from Ferencváros, Budapest, 2013-2019].
2019 35
Revista
Orv Hetil
Número de registro del estudio
PMID: 31736344

[Pan-European Registry on Helicobacter pylori management. Results from Ferencváros, Budapest, 2013-2019].

Buzás GM, Nyssen OP, Mégraud F, O'Morain C, Gisbert JP.

Orv Hetil. 2019 Nov;160(47):1856-1863. doi: 10.1556/650.2019.31553. PMID: 31736344



Abstract in English, Hu

Introduction: The Pan-European Registry on Helicobacter pylori management was conceived in 2013 to monitor eradication practices in Europe for 10 years. Aim: To assess the efficacy of different eradication regimens in a single outpatient clinic of gastroenterology. Method: Between 2013 and 2019, 247 patients were registered in a prospective non-interventional study. The infection was diagnosed either by endoscopy, histology, rapid urease test or 13C-urea breath test. As first-line treatment, the patients received either a 7-day triple regimen (any of PPI + amoxicillin + clarithromycin or tinidazole), 10-day modified sequential treatment (PPI + amoxicillin for 5 days + tinidazole and levofloxacin for 5 days), 10-day quadruple concomitant treatment (PPI + amoxicillin + tetracycline or doxycycline + metronidazole or tinidazole) or bismuth-based quadruple treatment. Bismuth or non-bismuth based quadruple or alternative regimens were given as second- or third-line treatment. Results: The eradication rates on per protocol basis were: 82.7% (95% confidence interval: 68.1-97.4) (first-line regimens), 85.2% (75.4-94.9) (sequential treatment), 95.1% (89.6-100) (concomitant treatment) and 82.6% (69.7-95.9) (bismuth-based quadruple regimen). Second-line regimens achieved 65.2% (48.2-83.0) and third-line therapy 54.5% (19.4-86.6), respectively. Conclusion: The first-line concomitant regimen was superior to triple and not significantly better than the sequential or bismuth-based treatment. Second- and third-line regimens achieved largely suboptimal results. Orv Hetil. 2019; 160(47): 1856-1863.

Keywords: Helicobacter pylori registry; Helicobacter pylori-regiszter; eradication; eradikáció; kezelés; treatment.