El Grupo Esófago-Estómago-Duodeno de la AEG fue creado en el año 1999 por 23 gastroenterólogos pertenecientes a 23 hospitales nacionales, distribuidos en 12 comunidades autónomas.
El grupo de trabajo inició los primeros estudios multicéntricos relacionados con la epidemiología y el tratamiento de la infección por Helicobacter pylori en España. Entre los años 2000 y 2004, se desarrollaron proyectos dirigidos al estudio de factores pronósticos relacionados con el cáncer gástrico y el linfoma MALT. Asimismo, se iniciaron los primeros estudios multicéntricos dirigidos al estudio de los factores de riesgo relacionados con la gastropatía por antiinflamatorios no esteroideos. Los resultados obtenidos en estos primeros estudios colaborativos contribuyeron de forma notable al desarrollo y consolidación del grupo de trabajo, con 27 trabajos multicéntricos publicados durante los últimos 10 años, 12 de ellos en los últimos 2 años, y otros 12 estudios abiertos en la actualidad.
El grupo se encuentra constituido actualmente por 56 gastroenterólogos pertenecientes a 31 hospitales nacionales de 12 comunidades autónomas, siendo las líneas principales de investigación la infección por Helicobacter pylori, la enfermedad celíaca y la esofagitis eosinofílica.
Los coordinadores del grupo han sido por orden cronológico:
- Enrique Quintero
- Xavier Calvet
- Javier Pérez Gisbert
- Javier Molina Infante
Objetivos
- Agrupar a todos los profesionales especialmente interesados en el conocimiento de la patología del esófago, estómago e intestino delgado, con el fin de compartir conocimientos en esta área de trabajo, así como en áreas afines.
- Fomentar el conocimiento y difusión de aquellos temas o conceptos más actuales sobre las enfermedades del tracto digestivo superior, permitiendo una actualización constante de los profesionales interesados en esta área.
- Fomentar la investigación básica y clínica en el campo de las enfermedades esofágicas, gástricas o del intestino delgado.
- Integrar a investigadores españoles en las actividades de nuestro grupo de trabajo, así como con otros grupos tanto a nivel nacional como internacional.
- Colaborar en la formación de profesionales, especialmente en el área de conocimiento de las enfermedades del esófago, estómago e intestino delgado.
- Colaborar en el seno de nuestro grupo de trabajo, así como en la Asociación Española de Gastroenterología (AEG), para la mejora y fomento de nuestra especialidad.
Coordinador de Esófago-Estómago-Duodeno
Javier Alcedo
European Registry on Helicobacter pylori Management (Hp-EuReg)
About us
This prospective multicenter registry of the clinical practice of European gastroenterologists on the management of Helicobacter pylori infection and its treatment is supported by the European Helicobacter & Microbiota Study Group and the Asociación Española de Gastroenterología.
Javer P. Gisbert
Principal investigator
Olga P. Nyssen
Ignasi Puig
Scientific directors
Francis Megraud, Colm'O Morain, Olga P. Nyssen, Ignasi Puig & Javier P. Gisbert
Scientific committee
Anna Cano
Technical Project Manager
Main results
Last outstanding publication
Number of patients included per country
Number of patients included by year
Increase in eradication rates
Publications on behalf of the Hp-EuReg investigators
Caldas, M.; Pérez-Aisa, Á.; Castro-Fernández, M.; Bujanda, L.; Lucendo, A.J.; Rodrigo, L.; Huguet, J.M.; Pérez-Lasala, J.; Molina-Infante, J.; Barrio, J.; Fernández-Salazar, L.; Lanas, Á.; Perona, M.; Domínguez-Cajal, M.; Ortuño, J.; Gómez-Rodríguez, B.J.; Almela, P.; Botargués, J.M.; Núñez, Ó.; Modolell, I.; Gómez, J.; Ruiz-Zorrilla, R.; De la Coba, C.; Huerta, A.; Iyo, E.; Pozzati, L.; Antón, R.; Barenys, M.; Angueira, T.; Fernández-Bermejo, M.; Campillo, A.; Alcedo, J.; Pajares-Villaroya, R.; Mego, M.; Bermejo, F.; Dominguez-Jiménez, J.L.; Titó; L; Fernández, N.; Pabón-Carrasco, M.; Cosme, Á.; Mata-Romero, P.; Alcaide, N.; Ariño, I.; Di Maira, T.; Garre, A.; Puig, I.; Nyssen, O.P.; Megraud, F.; O’Morain, C.; Gisbert, J.P.; European Registry on Helicobacter pylori Management: Effectiveness of First and Second-Line Treatment in Spain. Antibiotics (in press)
Olga P. Nyssen, Dino Vaira, Bojan Tepes, Limas Kupcinskas, Dmitry Bordin, Ángeles Pérez-Aisa, Antonio Gasbarrini, Manuel Castro-Fernández, Luis Bujanda, Ana Garre, Alfredo Lucendo, Liudmila Vologzhanina, Natasa Brglez Jurecic, Luis Rodrigo-Sáez, Jose María Huguet Malavés, Irina Voynovan, Jorge Perez Lasala, Pilar Mata Romero, Miroslav Vujasinovic, Rustam Abdulkhakov, Jesús Barrio, Luis Fernandez-Salazar, Francis Mégraud, Colm O’Morain, Javier P. Gisbert. Room for improvement in the treatment of Helicobacter pylori infection: lessons from the European Registry on H. pylori management (Hp-EuReg) J Clin Gastroenterol (in press)
Nyssen OP, Bordin D, Tepes B, Pérez-Aisa Á, Vaira D, Caldas M, Bujanda L, Castro-Fernandez M, Lerang F, Leja M, Rodrigo L, Rokkas T, Kupcinskas L, Pérez-Lasala J, Jonaitis L, Shvets O, Gasbarrini A, Simsek H, Axon ATR, Buzás G, Machado JC, Niv Y, Boyanova L, Goldis A, Lamy V, Tonkic A, Przytulski K, Beglinger C, Venerito M, Bytzer P, Capelle L, Milosavljević T, Milivojevic V, Veijola L, Molina-Infante J, Vologzhanina L, Fadeenko G, Ariño I, Fiorini G, Garre A, Garrido J, F Pérez C, Puig I, Heluwaert F, Megraud F, O'Morain C, Gisbert JP. European Registry on Helicobacter pylori management (Hp-EuReg): patterns and trends in first-line empirical eradication prescription and outcomes of 5 years and 21 533 patients. Gut 2021 Jan;70(1):40-54. doi:
10.1136/gutjnl-2020-321372. Epub 2020 Sep 21. PMID:
32958544.
Nyssen OP, Perez-Aisa A, Castro-Fernandez M, Pellicano R, Huguet JM, Rodrigo L, Ortuño J, Gomez-Rodriguez BJ, Pinto RM, Areia M, Perona M, Nuñez O, Romano M, Gerarda Gravina A, Pozzati L, Fernandez-Bermejo M, Venerito M, Malfertheiner P, Fernanadez-Salazar L, Gasbarrini A, Vaira D, Puig I, Megraud F, O'Morain C, Gisbert JP. European Registry on Helicobacter pylori Management: single-capsule bismuth quadruple therapy is effective in real-world clinical practice. United European Gastroenterol J. 2020 Nov 11:2050640620972615. doi:
10.1177/2050640620972615. Epub ahead of print. PMID:
33176617.
Tepes B, Brglez Jurecic N, Tepes K, Espada Sanchez M, Perez Nyssen O, Smith S, Mégraud F, Gisbert JP. Helicobacter pylori eradication rates in Slovenia in the period from 2017 to 2019 - data from the European Registry on Helicobacter pylori Management (Hp-EuReg). Dig Dis. 2020 Oct 23. doi:
10.1159/000512506. Epub ahead of print. PMID:
33099549.
Nyssen OP, Perez-Aisa A, Rodrigo L, Castro M, Mata Romero P, Ortuño J, Barrio J, Huguet JM, Modollel I, Alcaide N, Lucendo A, Calvet X, Perona M, Gomez B, Gomez Rodriguez BJ, Varela P, Jimenez-Moreno M, Dominguez-Cajal M, Pozzati L, Burgos D, Bujanda L, Hinojosa J, Molina-Infante J, Di Maira T, Ferrer L, Fernández-Salazar L, Figuerola A, Tito L, de la Coba C, Gomez-Camarero J, Fernandez N, Caldas M, Garre A, Resina E, Puig I, O'Morain C, Megraud F, Gisbert JP. Bismuth quadruple regimen with tetracycline or doxycycline versus three-in-one single capsule as third-line rescue therapy for Helicobacter pylori infection: Spanish data of the European Helicobacter pylori Registry (Hp-EuReg). Helicobacter. 2020 Oct;25(5):e12722. doi:
10.1111/hel.12722. Epub 2020 Jul 13. PMID:
32656898.
Graham DY, El-Serag HB. European Registry on Helicobacter pylori management shows that gastroenterology has largely failed in its efforts to guide practitioners. Gut. 2021 Jan;70(1):1-2. doi:
10.1136/gutjnl-2020-322385. Epub 2020 Sep 21. PMID:
32958543.
Nyssen OP, Pérez-Aisa Á, Tepes B, Rodrigo-Sáez L, Romero PM, Lucendo A, Castro-Fernández M, Phull P, Barrio J, Bujanda L, Ortuño J, Areia M, Brglez Jurecic N, Huguet JM, Alcaide N, Voynovan I, María Botargues Bote J, Modolell I, Pérez Lasala J, Ariño I, Jonaitis L, Dominguez-Cajal M, Buzas G, Lerang F, Perona M, Bordin D, Axon T, Gasbarrini A, Marcos Pinto R, Niv Y, Kupcinskas L, Tonkic A, Leja M, Rokkas T, Boyanova L, Shvets O, Venerito M, Bytzer P, Goldis A, Simsek I, Lamy V, Przytulski K, Kunovský L, Capelle L, Milosavljevic T, Caldas M, Garre A, Mégraud F, O'Morain C, Gisbert JP; Hp-EuReg Investigators. Helicobacter pylori first-line and rescue treatments in patients allergic to penicillin: Experience from the European Registry on H pylori management (Hp-EuReg). Helicobacter. 2020 Jun;25(3):e12686. doi:
10.1111/hel.12686. Epub 2020 Mar 16. PMID:
32173974.
Bordin DS, Voynovan IN, Embutnieks YV, Nyssen OP, Megraud F, O Morain C, Perez-Gisbert J. [European registry on Helicobacter pylori management (Hp-EuReg) as a tool to evaluate and improve clinical practice in Moscow]. Ter Arkh. 2020 Apr 27;92(2):12-18. Russian. doi:
10.26442/00403660.2020.02.000567. PMID:
32598712.
McNicholl AG, Bordin DS, Lucendo A, Fadeenko G, Fernandez MC, Voynovan I, Zakharova NV, Sarsenbaeva AS, Bujanda L, Perez-Aisa Á, Vologzhanina L, Zaytsev O, Ilchishina T, Coba C, Lasala JP, Alekseenko S, Modolell I, Molina-Infante J, Ruiz-Zorrilla Lopez R, Alonso-Galan H, Moreno NF, Hinojosa J, Santaella I, Varela P, Gonzalez-Cordero PL, Barrio J, Dominguez-Jimenez JL, Nuñez O, Alcedo J, Nyssen OP, Caldas M, Donday MG, Shvetz O, Megraud F, O'Morain C, Gisbert JP. Combination of Bismuth and Standard Triple Therapy Eradicates Helicobacter pylori Infection in More than 90% of Patients. Clin Gastroenterol Hepatol. 2020 Jan;18(1):89-98. doi:
10.1016/j.cgh.2019.03.048. Epub 2019 Apr 10. PMID:
30978536.
Buzás GM, Nyssen OP, Mégraud F, O'Morain C, Gisbert JP. Páneurópai regiszter: a Helicobacter pylori-fertőzés kezelése. Ferencvárosi adatok, 2013–2019 [Pan-European Registry on Helicobacter pylori management. Results from Ferencváros, Budapest, 2013-2019]. Orv Hetil. 2019 Nov;160(47):1856-1863. Hungarian. doi:
10.1556/650.2019.31553. PMID:
31736344.
McNicholl AG, O'Morain CA, Megraud F, Gisbert JP; As Scientific Committee of the Hp-Eureg on Behalf of the National Coordinators. Protocol of the European Registry on the management of Helicobacter pylori infection (Hp-EuReg). Helicobacter. 2019 Oct;24(5):e12630. doi:
10.1111/hel.12630. Epub 2019 Jul 8. PMID:
31282060.
Bordin DS, Embutnieks YV, Vologzhanina LG, Ilchishina TA, Voynovan IN, Sarsenbaeva AS, Zaitsev OV, Alekseenko SA, Abdulkhakov RA, Dehnich NN, Osipenko MF, Livzan MA, Tsukanov VV, Burkov SG, Bakulina NV, Plotnikova EY, Tarasova LV, Maev IV, Kucheryavyi YA, Baryshnikova NV, Butov MA, Kolbasnikov SV, Pakhomova AL, Zhestkova TV, Baranovsky AY, Abdulhakov SR, Ageeva EA, Lyalyukova EA, Vasyutin AV, Golubev NN, Savilova IV, Morkovkina LV, Kononova AG, Megraud F, O'Morain C, Ramas M, Nyssen OP, McNicholl AG, Gisbert JP. [European registry Helicobacter pylori (Hp-EuReg): how has clinical practice changed in Russia from 2013 to 2018 years]. Ter Arkh. 2019 Feb 15;91(2):16-24. Russian. doi:
10.26442/00403660.2019.02.000156. PMID:
32598623.
Bordin DS, Embutnieks YV, Vologzhanina LG, Il'chishina TA, Voinovan IN, Sarsenbaeva AS, Alekseenko SA, Zaitsev OV, Abdulkhakov RA, Osipenko MF, Livzan MA, Tsukanov VV, Burkov SG, Bakulina NV, Dekhnich NN, Tarasova LV, Plotnikova EY, Maev IV, Kucheryavyi YA, Baryshnikova NV, Butov MA, Kolbasnikov SV, Pakhomova AL, Zhestkova TV, Baranovskii AY, Abdulkhakov SR, Ageeva EA, Lyalyukova EA, Vasyutin AV, Golubev NN, Savilova IV, Morkovkina LV, Kononova AG, Megraud F, O'Morain C, Ramas M, Nyssen OP, McNicholl AG, Gisbert JP. European Registry on the management of Helicobacter pylori infection (Hp-EuReg): analysis of 2360 patients receiving first-line therapy in Russia. Ter Arkh. 2018 Feb 15;90(2):35-42. doi:
10.26442/terarkh201890235-42. PMID:
30701770.
Tepes B, Kastelic M, Vujasinovic M, Lampic P, Seruga M, Jurecic NB, Nyssen OP, Donday MG, O'Morain C, Megraud F, McNicholl AG, Gisbert JP. Helicobacter Pylori Treatment Results in Slovenia in the Period 2013-2015 as a Part of European Registry on Helicobacter Pylori Management. Radiol Oncol. 2017 Dec 7;52(1):1-6. doi:
10.1515/raon-2017-0055. PMID: 29520199; PMCID:
PMC5839075.
Bordin DS, Yanova OB, Abdulkhakov RA, Tsukanov VV, Livzan MA, Burkov SG, Zakharova NV, Plotnikova EY, Osipenko MF, Tarasova LV, Maev IV, Kucheryavyi YA, Butov MA, Sablin OA, Kolbasnikov SV, Voinovan IN, Abdulkhakov SR, Vasyutin AV, Lyalyukova EA, Golubev NN, Savilova IV, Grigoryeva LV, Kononova AG, O'Morain C, Ramas M, Mcnicholl AG, Gisbert JP. [European Registry on the management of Helicobacter pylori infection (Hp-EuReg protocol): The first results of Russian centers]. Ter Arkh. 2016;88(2):33-38. Russian. doi:
10.17116/terarkh201688233-38. PMID:
27030181.
Gisbert JP, Romano M, Gravina AG, Solís-Muñoz P, Bermejo F, Molina-Infante J, Castro-Fernández M, Ortuño J, Lucendo AJ, Herranz M, Modolell I, Del Castillo F, Gómez J, Barrio J, Velayos B, Gómez B, Domínguez JL, Miranda A, Martorano M, Algaba A, Pabón M, Angueira T, Fernández-Salazar L, Federico A, Marín AC, McNicholl AG. Helicobacter pylori second-line rescue therapy with levofloxacin- and bismuth-containing quadruple therapy, after failure of standard triple or non-bismuth quadruple treatments. Aliment Pharmacol Ther. 2015 Apr;41(8):768-75. doi:
10.1111/apt.13128. Epub 2015 Feb 23. PMID:
25703120
Buzás GM. Helicobacter pylori -- 2014 [Helicobacter pylori - 2014]. Orv Hetil. 2015 Feb 8;156(6):203-10. Hungarian. doi:
10.1556/OH.2015.30097. PMID:
25639633.
Molina-Infante J, Lucendo AJ, Angueira T, Rodriguez-Tellez M, Perez-Aisa A, Balboa A, Barrio J, Martin-Noguerol E, Gomez-Rodriguez BJ, Botargues-Bote JM, Gomez-Camarero J, Huerta A, Modolell I, Ariño I, Herranz-Bachiller MT, Bermejo F, McNicholl AG, O'Morain C, Gisbert JP; European Registry on H. pylori management (Hp‐EuReg). Optimised empiric triple and concomitant therapy for Helicobacter pylori eradication in clinical practice: the OPTRICON study. Aliment Pharmacol Ther. 2015 Mar;41(6):581-9. doi:
10.1111/apt.13069. Epub 2015 Jan 14. PMID:
25776067.
Gisbert JP, Pérez-Aisa A, Bermejo F, Castro-Fernández M, Almela P, Barrio J, Cosme A, Modolell I, Bory F, Fernández-Bermejo M, Rodrigo L, Ortuño J, Sánchez-Pobre P, Khorrami S, Franco A, Tomas A, Guerra I, Lamas E, Ponce J, Calvet X; H. pylori Study Group of the Asociación Española de Gastroenterología (Spanish Gastroenterology Association). Second-line therapy with levofloxacin after failure of treatment to eradicate helicobacter pylori infection: time trends in a Spanish Multicenter Study of 1000 patients. J Clin Gastroenterol. 2013 Feb;47(2):130-5. doi:
10.1097/MCG.0b013e318254ebdd. PMID:
22647827.
Abstracts presented at international meetings
Newsletter: October 1st, 2020
Protocol of the European Registry on the management of Helicobacter pylori infection (Hp‐EuReg )
McNicholl AG, O'Morain CA, Megraud F, Gisbert JP; As Scientific Committee of the Hp-Eureg on Behalf of the National Coordinators. Helicobacter. 2019 Oct;24(5):e12630. doi: 10.1111/hel.12630. Epub 2019 Jul 8.PMID: 31282060 https://pubmed.ncbi.nlm.nih.gov/31282060/
Introduction
Helicobacter pylori selectively infects the human stomach, being the most prevalent chronic infection in the world. H pylori presence causes chronic gastritis in 100% of infected patients and is the major cause of relevant diseases such as atrophic gastritis, peptic ulcer disease, and gastric cancer; it is for this reason that from a public health standpoint, it is considered a high-impact pathogen, responsible of a significant morbidity and mortality. Nowadays, there are consensus and clinical guidelines regarding the infection management at a European level and in most of European countries, but no data have shown the level of implementation of these recommendations. The high costs that this infection carries both socially and to the health system require the continuous and systematic assessment of the diagnostic and treatment strategies, as well as the accessibility to diagnostic methods and most efficient drugs.
Aim
To register the diagnosis, management strategies, and treatment of H pylori-infected adult patients in the Digestive Services outpatient clinics throughout Europe.
Methods
Noninterventionist prospective multicentre international Registry promoted by the European Helicobacter and Microbiota Study Group. National Coordinators will select recruiting gastroenterologists in their country that will register the H pylori-related routine clinical practice consultations they receive in an electronic case report form (e-CRF) provided by AEG-REDCap. Variables retrieved will include clinical, diagnostic, treatment, eradication confirmation, and outcome data. The database will allow researchers to perform specific subanalyses after approval by the Scientific Committee of the study.
Javier P. Gisbert MD, PhD
Principal Investigator
Olga P. Nyssen BsC, PhD
Scientific Directors
Ignasi Puig MD, PhD
Scientific Directors
Anna Cano
Scientific Directors
National Coordinators
|
Country |
National coordinator |
|
|
AZERBAIJAN |
Dr. Gulustan Babayeva |
E-Mail |
|
BELGIUM |
Dr. Vincent Lamy |
|
|
BULGARIA |
Dr. Lyudmila Boyanova |
|
|
CROATIA |
Dr. Ante Tonkić |
E-Mail |
|
CZECH REPUBLIC |
Dr. Lumír Kunovský |
E-Mail |
|
DENMARK |
Dr. Peter Bytzer |
E-Mail |
|
FINLAND |
Dr. Ari Ristimaki |
|
|
FRANCE |
Dr. Francis Megraud |
|
|
GERMANY |
Dr. Marino Venerito |
E-Mail |
|
GREECE |
Dr. Theodore Rokkas |
|
|
HUNGARY |
Dr. Gyorgy M Buzas |
E-Mail |
|
IRELAND |
Dr. Sinead Smith/td>
| E-Mail |
|
ISREAL |
Dr. Yaron Niv |
E-Mail |
|
ITALY |
Dr. Antonio Gasbarrini |
E-Mail |
|
LATVIA |
Dr. Marcis Leja |
|
|
LITHUANIA |
Dr. Juozas Kupčinskas |
E-Mail |
|
NORWAY |
Dr. Frode Lerand |
E-Mail |
|
POLAND |
Dr. Wojciech Marlicz |
E-Mail |
|
PORTUGAL |
Dr. Ricardo Marcos Pinto |
E-Mail |
|
ROMANIA |
Dr. Adrian Goldis |
E-Mail |
|
RUSSIA |
Dr. Dmitry Bordin |
E-Mail |
|
SERBIA |
Dr. Vladimir Milivojevic |
E-Mail |
|
SLOVENIA |
Dr. Bojan Tepes |
E-Mail |
|
SPAIN |
Dr. Javier P. Gisbert |
E-Mail |
|
SWITZERLAND |
Dr. Christoph Beglinger |
|
|
THE NETHERLANDS |
Dr. Lisette Capelle |
|
|
TURKEY |
Dr. Ilkay Simsek |
|
|
UNITED KINGDOM |
Dr. Perminder Phull |
E-Mail |
|
UKRAINE |
Dr. Oleg Shvets |
|
En breve actualizaremos la lista de miembros del Grupo de Trabajo
